Description

4-Nitro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures containing the nitro-trifluoromethylphenyl motif.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting specific receptor sites.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the nitro and trifluoromethyl groups confer unique biological activity.
• Material Science: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Enables the efficient introduction of the 4-nitro-3-(trifluoromethyl)phenyl group into complex molecules via palladium-catalyzed cross-coupling.
• Library Synthesis: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.
• Ligand & Catalyst Development: Acts as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Nitro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester
CAS No.	1402615-44-4
Molecular Formula	C13H15BF3NO4
Molecular Weight	317.07 g/mol
Synonyms	4-Nitro-3-(trifluoromethyl)benzeneboronic acid pinacol ester; 2-(4-Nitro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Nitro-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol 4-Nitro-3-(trifluoromethyl)phenylboronate; 4-Nitro-3-trifluoromethylphenylboronic acid pinacol ester; Boronic acid, B-[4-nitro-3-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); CAS 1402615-44-4
EINECS	Contact for details

Quality Control

Our 4-Nitro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.