Description

tert-Butyl (2S,4S)-Rel-4-Amino-2-(Hydroxymethyl)Piperidine-1-Carboxylate is a high-purity, stereochemically defined chiral piperidine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a protected, functionalized scaffold essential for the efficient synthesis of complex bioactive molecules, particularly in medicinal chemistry. This compound is primarily needed by research institutions and pharmaceutical manufacturers developing novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in antiviral and anticancer drug discovery programs.
• Protease Inhibitor Synthesis: Core structural component in the development of inhibitors targeting various proteases, such as HCV NS3/4A or HIV protease.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific stereochemistry and functional groups.
• Peptidomimetic Development: Serves as a constrained, non-natural amino acid analog in the design of peptide-like molecules with enhanced metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Chemical Biology Probes: Utilized in the creation of tool compounds and molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl (2S,4S)-Rel-4-Amino-2-(Hydroxymethyl)Piperidine-1-Carboxylate
CAS No.	1402249-04-0
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	1-Boc-4-amino-2-hydroxymethylpiperidine (2S,4S)-rel; (2S,4S)-rel-1-(tert-Butoxycarbonyl)-4-amino-2-piperidinemethanol; (2S,4S)-rel-4-Amino-2-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester; rel-(2S,4S)-1-N-Boc-4-amino-2-piperidinemethanol; 1-N-Boc-4-amino-2-piperidinemethanol (2S,4S)-rel; Boc-4-Amino-2-hydroxymethylpiperidine (2S,4S)-rel; tert-Butyl (2S,4S)-rel-4-amino-2-(hydroxymethyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl (2S,4S)-Rel-4-Amino-2-(Hydroxymethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.