Description

4-(n-(3-Methoxypropyl)Sulfamoyl)-2-Trifluoromethylphenylboronic Acid is a specialized organoboronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a sulfamoyl moiety that offers additional points for derivatization and solubility modification. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, particularly those targeting new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those containing trifluoromethyl and sulfonamide pharmacophores for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the boronic acid group enables efficient construction of biaryl structures.
• Material Science: Building block for advanced organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, where its structure allows for fine-tuning of electronic properties.
• Chemical Biology & Proteomics: Employed in the development of activity-based probes and inhibitors that target enzymes with serine or threonine in their active sites.
• Cross-Coupling Reactions: Essential reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling for the formation of carbon-carbon bonds between aryl or vinyl groups.
• Library Synthesis: High-value starting material for combinatorial chemistry and high-throughput screening libraries in drug discovery programs.

Basic Information

Item	Details
Product Name	4-(n-(3-Methoxypropyl)Sulfamoyl)-2-Trifluoromethylphenylboronic Acid
CAS No.	1402238-35-0
Molecular Formula	C11H15BF3NO4S
Molecular Weight	325.11 g/mol
Synonyms	4-[(3-Methoxypropyl)sulfamoyl]-2-(trifluoromethyl)benzeneboronic Acid; [4-[(3-Methoxypropyl)sulfamoyl]-2-(trifluoromethyl)phenyl]boronic Acid; 2-Trifluoromethyl-4-(N-3-methoxypropylsulfamoyl)phenylboronic Acid; 4-(N-(3-Methoxypropyl)sulfamoyl)-2-(trifluoromethyl)benzeneboronic Acid; B-[4-[[(3-Methoxypropyl)amino]sulfonyl]-2-(trifluoromethyl)phenyl]boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-(n-(3-Methoxypropyl)Sulfamoyl)-2-Trifluoromethylphenylboronic Acid undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and cGMP manufacturing environments. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its boronic acid nature and sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.