Description

4-Fluoro-2-(Methylsulfonyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid group and a methylsulfonyl substituent on a fluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics (OPVs).
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Fluoro-2-(Methylsulfonyl)Phenylboronic Acid
CAS No.	1402238-31-6
Molecular Formula	C7H8BFO4S
Molecular Weight	218.01 g/mol
Synonyms	(4-Fluoro-2-(methylsulfonyl)phenyl)boronic acid; 2-(Methylsulfonyl)-4-fluorobenzeneboronic acid; 4-Fluoro-2-methylsulfonylbenzeneboronic acid; B-[4-Fluoro-2-(methylsulfonyl)phenyl]boronic acid; 4-Fluoro-2-methanesulfonylbenzeneboronic acid; Boronic acid, B-[4-fluoro-2-(methylsulfonyl)phenyl]-; CAS 1402238-31-6
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Methylsulfonyl)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.