Description

2-(3-Chloro-4-Fluoro-5-Methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity, advanced boronic ester building block critical for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research and development teams for creating novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A pivotal reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, essential for synthesizing biaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing fluorinated and chlorinated aromatic cores with precise substitution patterns.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides that benefit from the unique properties of the halogenated methylphenyl group.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the boronic ester functionality allows for modular assembly of conjugated systems.
• Chemical Biology & Probe Development: Utilized as a precursor for bioconjugation or as a tag in the synthesis of molecular probes and diagnostic agents.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-(3-Chloro-4-Fluoro-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1402238-26-9
Molecular Formula	C₁₃H₁₇BClFO₂
Molecular Weight	285.53 g/mol
Synonyms	(3-Chloro-4-fluoro-5-methylphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-fluoro-5-methylbenzeneboronic acid pinacol ester; (3-Chloro-4-fluoro-5-methylphenyl)pinacolboronate; Pinacol (3-chloro-4-fluoro-5-methylphenyl)boronate; Boronic acid, B-(3-chloro-4-fluoro-5-methylphenyl)-, 1,1-dimethylethyl ester (9CI); 1402238-26-9
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-4-Fluoro-5-Methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.