Description

2-Fluoro-4-(Methylsulfonyl)Benzyl Bromide is a high-purity, multi-functional organic building block essential for advanced chemical synthesis. Its core value lies in the reactive benzyl bromide moiety and the electron-withdrawing methylsulfonyl group, which make it a critical intermediate for constructing complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its fluorine and sulfone functional groups.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in specialty polymers and advanced materials.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce the benzylsulfonyl moiety.
• Nucleophilic Substitution: The benzyl bromide group is highly reactive for nucleophilic substitution, enabling the attachment of various amines, thiols, and other nucleophiles.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes or molecular tags for proteomics and diagnostic applications.

Basic Information

Product Name	2-Fluoro-4-(Methylsulfonyl)Benzyl Bromide
CAS No.	1401796-84-6
Molecular Formula	C8H8BrFO2S
Molecular Weight	267.12 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-4-(methylsulfonyl)benzene; 4-(Bromomethyl)-3-fluoro-1-(methylsulfonyl)benzene; α-Bromo-2-fluoro-4-(methylsulfonyl)toluene; 2-Fluoro-4-(methylsulfonyl)benzyl bromide; 2-Fluoro-4-methanesulfonylbenzyl bromide; (2-Fluoro-4-(methylsulfonyl)phenyl)methyl bromide; 4-(Bromomethyl)-3-fluorophenyl methyl sulfone
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Methylsulfonyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.