Description

1-Bromo-2-Ethynyl-3-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block designed for advanced organic synthesis. This compound is valued for its unique combination of reactive sites—a bromine substituent, an ethynyl group, and a fluorine atom—which enable precise and diverse molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly for constructing complex heterocycles and fluorinated bioactive molecules via Sonogashira, Suzuki, or Buchwald-Hartwig cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and ethynyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-2-Ethynyl-3-Fluorobenzene
CAS No.	1401670-91-4
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	2-Bromo-1-ethynyl-3-fluorobenzene; 3-Fluoro-2-bromophenylacetylene; 1-Ethynyl-2-bromo-3-fluorobenzene; 2-Bromo-3-fluorophenylacetylene; (2-Bromo-3-fluorophenyl)ethyne; 1401670-91-4
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethynyl-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.