Description

Solifenacin-D5 Hydrochloride is a deuterated isotopologue of the active pharmaceutical ingredient solifenacin, specifically labeled with five deuterium atoms. This compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers involved in the development and quality control of urological medications.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of solifenacin and its metabolites in biological matrices (e.g., plasma, urine) during clinical trials and bioequivalence studies.
• Deuterated Reference Material: Used in method development and validation to account for matrix effects and instrument variability in mass spectrometry.
• Pharmaceutical Research: Supports drug metabolism and pharmacokinetics (DMPK) studies for antimuscarinic agents targeting overactive bladder (OAB).
• Quality Control & Assurance: Employed in analytical laboratories to ensure the specificity and accuracy of assays for solifenacin succinate drug products.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies of drug absorption, distribution, metabolism, and excretion (ADME).

Basic Information

Product Name	Solifenacin-D5 Hydrochloride
CAS No.	1401416-00-9
Molecular Formula	C23H21D5N2O2•HCl
Molecular Weight	407.98 g/mol (approx.)
Synonyms	(3R)-1-Azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate-d5 hydrochloride; YM905-d5 hydrochloride; Vesicare-d5 hydrochloride; (1S,3'R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3'-carboxylic acid quinuclidin-3'-yl ester-d5 hydrochloride; Solifenacin (phenyl-d5) hydrochloride; Solifenacin-d5 HCl
EINECS	Contact for details

Quality Control

Our Solifenacin-D5 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D5), and chemical purity. Certificates of Analysis (COA) detailing all test results are provided to ensure full traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.