Description

(4,4-Difluorocyclohex-1-En-1-Yl)Boronic Acid is a high-value organoboron building block, specifically a cyclic alkenyl boronic acid derivative. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in advanced chemical synthesis. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating fluorinated scaffolds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to construct novel, fluorinated heterocyclic compounds for the development of new pesticides and herbicides with improved efficacy.
• Material Science: Serves as a precursor for creating specialized fluorinated polymers and advanced organic electronic materials.
• Chemical Synthesis: A versatile reagent in medicinal chemistry for parallel synthesis and library generation of complex, fluorinated small molecules.
• Ligand & Catalyst Development: Employed in the preparation of novel boron-containing ligands for catalytic applications.
• Fluorine Chemistry Research: A valuable tool for academic and industrial research exploring the unique properties imparted by the difluorocyclohexenyl motif.

Basic Information

Product Name	(4,4-Difluorocyclohex-1-En-1-Yl)Boronic Acid
CAS No.	1401165-15-8
Molecular Formula	C6H9BF2O2
Molecular Weight	157.95 g/mol
Synonyms	4,4-Difluoro-1-cyclohexene-1-boronic acid; (4,4-Difluorocyclohex-1-en-1-yl)boronic acid; 4,4-Difluorocyclohex-1-en-1-ylboronic acid; B-(4,4-Difluorocyclohex-1-en-1-yl)boronic acid; 4,4-Difluorocyclohexenylboronic Acid; 1-Borono-4,4-difluorocyclohex-1-ene; (4,4-Difluoro-1-cyclohexenyl)boronic Acid
EINECS	Contact for details

Quality Control

Our (4,4-Difluorocyclohex-1-En-1-Yl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (1H, 11B, 19F) and HPLC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
NMR Purity (1H)	≥95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.