Description

1R,4R,5R-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a rigid, chiral bicyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel, biologically active molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of neurology and enzymology.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained, three-dimensional structure which can influence receptor binding and pharmacokinetic properties.
• Protease Inhibitor Synthesis: Serves as a core scaffold or precursor in the synthesis of potential protease inhibitors, given the presence of the carbamate-protected amine functionality.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in asymmetric synthesis to induce stereoselectivity in complex molecular constructions.
• Chemical Biology Probes: Used in the development of chemical probes for studying enzyme function and biological pathways in academic and industrial research settings.
• GMP Manufacturing: Suitable for use in cGMP-compliant processes for the production of active pharmaceutical ingredients (APIs) under stringent quality control.

Basic Information

Product Name	1R,4R,5R-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1400808-13-0
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(1R,4R,5R)-5-[(tert-Butoxycarbonyl)amino]-2-azabicyclo[2.2.1]heptane; tert-Butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate; (1R,4R,5R)-N-Boc-2-azabicyclo[2.2.1]heptan-5-amine; (1R,4R,5R)-5-(Boc-amino)-2-azabicyclo[2.2.1]heptane; (1R,4R,5R)-2-Azabicyclo[2.2.1]heptane-5-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester; Bicyclo[2.2.1]heptane-2-azanyl, 5-[(1,1-dimethylethoxy)carbonyl]amino]-, (1R,4R,5R)-
EINECS	Contact for details

Quality Control

Our 1R,4R,5R-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.