Description

2-(2-(3-Fluorophenyl)Prop-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a vinylboronic ester derivative. This compound matters as a critical intermediate in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex fluorinated molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of new active ingredients and functional materials, leveraging its unique reactivity and the strategic fluorine substitution.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific fluorinated boronic ester motifs.

Basic Information

Product Name	2-(2-(3-Fluorophenyl)Prop-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1398771-28-2
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	3-Fluoro-β-methylstyrene pinacol boronate; (E)-2-(2-(3-Fluorophenyl)prop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(1-(3-Fluorophenyl)prop-1-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluorophenylpropenylboronic acid pinacol ester; 1-(3-Fluorophenyl)-1-propen-2-ylboronic acid pinacol ester; Vinylboronic ester, 3-fluoro derivative; B-(1-Methyl-2-(3-fluorophenyl)vinyl)pinacolborane
EINECS	Contact for details

Quality Control

Our 2-(2-(3-Fluorophenyl)Prop-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.