Description

Topotecan n-Oxide is a significant pharmaceutical intermediate and metabolite of the chemotherapeutic agent Topotecan. This compound is crucial for research and development in oncology, particularly in the study of drug metabolism, pharmacokinetics, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on cancer treatment.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of Topotecan and related camptothecin analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify Topotecan metabolites in biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, bioavailability, and clearance mechanisms of Topotecan.
• Oncology Research: Employed in preclinical studies to investigate the structure-activity relationships (SAR) and efficacy of topoisomerase I inhibitors.
• Impurity Profiling: Serves as a known impurity or degradation product reference in the quality control of Topotecan API batches to ensure purity and safety.
• Chemical Biology Studies: Used as a tool compound to probe the mechanisms of action and resistance associated with camptothecin-derived drugs.

Basic Information

Product Name	Topotecan n-Oxide
CAS No.	1398723-05-1
Molecular Formula	C23H23N3O6
Molecular Weight	437.45 g/mol
Synonyms	(S)-10-Hydroxy-9-[(dimethylamino)methyl]-7,11-dioxo-8-oxa-1-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-2,4,6,13,15,17-hexaen-6-ium-9-olate; Topotecan N-Oxide; Topotecan Oxide; 9-N-Oxide of Topotecan; HY-101433; Topotecan Metabolite
EINECS	Contact for details

Quality Control

Our Topotecan n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.