Description

(S)-(-)-Verapamil-D3 HCl (n-Methyl-D3) is a high-purity, deuterium-labeled internal standard of the calcium channel blocker verapamil, specifically designed for analytical applications. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry, where it serves as a reference for pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug development and bioanalysis.

Application

• Quantitative Bioanalysis: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the precise quantification of verapamil and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Drug Metabolism Studies: Facilitates the identification and quantification of metabolite formation, aiding in the understanding of metabolic pathways.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Supports method development and validation for monitoring verapamil levels in patient samples to ensure therapeutic efficacy and safety.
• Forensic & Doping Control Analysis: Employed in confirmatory testing protocols where high specificity and accuracy are required.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods according to FDA, EMA, and ICH guidelines.

Basic Information

Product Name	(S)-(-)-Verapamil-D3 HCl (n-Methyl-D3)
CAS No.	1398112-33-8
Molecular Formula	C27H35D3N2O4 • HCl
Molecular Weight	498.11 g/mol (for monohydrochloride)
Synonyms	(S)-Verapamil-d3 hydrochloride; (2S)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl-d3)amino}-2-(1-methylethyl)pentanenitrile hydrochloride; 5-{N-(3,4-Dimethoxyphenethyl)-N-(methyl-d3)amino}-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; Verapamil D3 (N-Methyl-D3) HCl; Verapamil-d3 internal standard; [N-Methyl-d3]-Verapamil hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Verapamil-D3 HCl (n-Methyl-D3) is manufactured and tested under strict quality systems to ensure the highest standards of purity, isotopic enrichment, and chemical integrity required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data (HPLC, NMR, MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.