Description

Rac Atomoxetine-D5 Hydrochloride CAS NO 1398065-95-6 is a deuterated isotopologue of the selective norepinephrine reuptake inhibitor atomoxetine, where five hydrogen atoms are replaced with deuterium. This compound is a critical analytical standard used for precise quantification and metabolic studies in pharmaceutical research and development. It is essential for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require high-purity reference materials for method development, validation, and bioanalytical testing.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable isotope-labeled internal standard for the accurate quantification of atomoxetine and its metabolites in biological matrices (e.g., plasma, urine).
• Pharmacokinetic and Metabolism Studies: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profile of atomoxetine in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Serves as a key component in developing and validating robust, sensitive, and specific analytical methods compliant with GLP and GMP guidelines.
• Pharmaceutical Quality Control (QC): Used in QC laboratories to ensure the identity, potency, and purity of atomoxetine active pharmaceutical ingredient (API) and finished dosage forms.
• Doping Control & Forensic Analysis: Applicable in sports anti-doping and forensic toxicology for the definitive identification and confirmation of atomoxetine.
• Reference Material for Regulatory Submissions: Provides essential data support for regulatory filings (e.g., FDA, EMA) requiring validated bioanalytical methods.

Basic Information

Product Name	Rac Atomoxetine-D5 Hydrochloride
CAS No.	1398065-95-6
Molecular Formula	C17H16D5NO•HCl
Molecular Weight	304.85 g/mol (approx.)
Synonyms	(±)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine-D5 hydrochloride; (R,S)-Tomoxetine-D5 hydrochloride; LY139603-D5; (R,S)-N-Methyl-3-phenyl-3-(2-methylphenoxy)propan-1-amine-D5 hydrochloride; Atomoxetine (D5) hydrochloride (racemic); Rac-Tomoxetine-D5 hydrochloride; Rac-Atomoxetine-D5 HCl
EINECS	Contact for details

Quality Control

Our Rac Atomoxetine-D5 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ²H, ¹³C), HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results against stringent internal specifications. We support research requiring traceable and reliable reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (²H NMR/MS)	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.