Description

Guanfacine-A,A-D2 Hcl is a deuterated analog of the α-2A adrenergic receptor agonist Guanfacine hydrochloride, specifically labeled at two positions. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical researchers, analytical laboratories, and CROs engaged in the development and validation of LC-MS/MS assays for the parent drug.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a deuterated internal standard for the precise quantification of Guanfacine in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Guanfacine.
• Bioanalytical Method Development & Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring and clinical trial sample analysis for drugs containing Guanfacine.
• Forensic Toxicology: Can be utilized in confirmatory testing for the presence of Guanfacine in forensic samples.
• Pharmaceutical Quality Control: Potential use in advanced impurity profiling and stability-indicating assay methods.

Basic Information

Product Name	Guanfacine-A,A-D2 Hcl
CAS No.	1398065-88-7
Molecular Formula	C9H7D2Cl2N3O•HCl
Molecular Weight	279.56 g/mol (for monoisotopic)
Synonyms	Guanfacine-d2 Hydrochloride; [A,A-D2]-Guanfacine HCl; N-Amidino-2-(2,6-dichlorophenyl)acetamide-d2 Hydrochloride; 2-[(2,6-Dichlorophenyl)acetyl]-1,1-dideuterio-hydrazinecarboximidamide Hydrochloride; Guanfacine (A,A-D2) HCl; Deuterated Guanfacine HCl; STABLE ISOTOPE Guanfacine-d2; BRN 3917466-d2
EINECS	Contact for details

Quality Control

Every batch of Guanfacine-A,A-D2 Hcl is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment, ensuring compliance with the rigorous standards required for analytical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.