Description

Clomipramine D3 Hydrochloride is a deuterated isotopologue of the tricyclic antidepressant clomipramine, specifically labeled with three deuterium atoms. This compound is a critical internal standard used in quantitative analytical methods, ensuring the highest accuracy and reliability in pharmaceutical research and development. It is essential for laboratories in the pharmaceutical, contract research organization (CRO), and analytical chemistry sectors requiring precise measurement of clomipramine and its metabolites in complex biological matrices.

Application

• Primary use as an internal standard for the quantification of clomipramine in bioanalytical studies using LC-MS/MS and GC-MS.
• Metabolite profiling and pharmacokinetic (PK) studies in drug discovery and development.
• Forensic and clinical toxicology analysis for the accurate determination of clomipramine levels.
• Quality control and method validation in pharmaceutical manufacturing to ensure batch consistency.
• Stability studies and degradation pathway analysis of clomipramine formulations.
• Research into the pharmacodynamics and metabolic pathways of tricyclic antidepressants.

Basic Information

Product Name	Clomipramine D3 Hydrochloride
CAS No.	1398065-86-5
Molecular Formula	C19H20D3ClN2•HCl
Molecular Weight	359.75 g/mol (for monoisotopic mass)
Synonyms	3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-d3 hydrochloride; Clomipramine-d3 HCl; Deuterated Clomipramine Hydrochloride; Clomipramine (phenyl-d3) Hydrochloride; Anafranil-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our Clomipramine D3 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.