Description

(±)-Miconazole-D5 Nitrate (2,4-Dichlorobenzyloxy-D5) is a deuterated analog of the widely used antifungal agent, miconazole nitrate. This compound is specifically designed for use as an internal standard in quantitative analytical methods, providing superior accuracy and reliability in mass spectrometry-based assays. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors. The deuterium labeling ensures minimal interference with the analyte of interest, enabling precise pharmacokinetic, metabolic, and stability studies.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for the quantification of miconazole in biological matrices (plasma, serum, tissue) during drug development and therapeutic drug monitoring.
• Pharmaceutical Research & Development: Used in method development and validation for assay specificity, accuracy, and precision in accordance with ICH guidelines.
• Metabolite Identification Studies: Serves as a stable isotope-labeled reference to distinguish drug-derived metabolites from endogenous compounds in mass spectrometry.
• Quality Control & Stability Testing: Employed in impurity profiling and stability-indicating assay methods for miconazole nitrate drug substances and finished products.
• Forensic and Anti-Doping Analysis: Facilitates the accurate detection and quantification of miconazole in complex samples for forensic investigations or sports anti-doping controls.
• Academic Research: Supports biochemical and pharmacological studies investigating the mechanism of action and metabolism of antifungal imidazole derivatives.

Basic Information

Product Name	(±)-Miconazole-D5 Nitrate (2,4-Dichlorobenzyloxy-D5)
CAS No.	1398065-80-9
Molecular Formula	C18H9D5Cl2N3O·HNO3
Molecular Weight	~ 485.3 g/mol (deuterated form)
Synonyms	Miconazole-d5 nitrate; 1-[2-(2,4-Dichlorobenzyloxy-d5)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate; Deuterated Miconazole Nitrate; Miconazole Nitrate-d5; Miconazole (2,4-dichlorobenzyloxy-d5) Nitrate; (±)-1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy-d5]phenethyl)imidazole mononitrate; Miconazole-d5 Internal Standard.
EINECS	Contact for details

Quality Control

Every batch of our (±)-Miconazole-D5 Nitrate (2,4-Dichlorobenzyloxy-D5) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and impurity profiles. Our quality commitment ensures reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.