Description

(±)-Phenoxybenzamine-D5 Hcl (Benzyl-2,3,4,5,6-D5) CAS NO 1398065-71-8 is a deuterium-labeled analog of the α-adrenergic receptor antagonist phenoxybenzamine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors, particularly for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of phenoxybenzamine.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking and quantification of the parent drug and its metabolites in biological matrices like plasma, serum, and urine.
• Bioanalytical Method Development and Validation: Used to establish robust, accurate, and reproducible analytical methods compliant with FDA and ICH guidelines.
• Drug Impurity Profiling: Assists in the identification and quantification of related substances and degradation products in active pharmaceutical ingredients (APIs).
• Clinical Research: Supports studies investigating the pharmacodynamics and therapeutic monitoring of α-blocker therapies.
• Forensic and Doping Control Analysis: Applied in specialized testing laboratories for the definitive identification and measurement of specific compounds.

Basic Information

Product Name	(±)-Phenoxybenzamine-D5 Hcl (Benzyl-2,3,4,5,6-D5)
CAS No.	1398065-71-8
Molecular Formula	C18H17D5ClNO•HCl
Molecular Weight	340.31 g/mol (approx.)
Synonyms	Phenoxybenzamine-d5 hydrochloride; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine-d5 hydrochloride; Benzyl-2,3,4,5,6-d5-phenoxybenzamine hydrochloride; Dibenzyline-d5 (labeled analog); SKF-688A-d5; NSC-34031-d5; Deuterated Phenoxybenzamine HCl; [Benzyl-d5]-Phenoxybenzamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our (±)-Phenoxybenzamine-D5 Hcl is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Comprehensive testing includes identity confirmation by spectroscopic methods (NMR, IR), purity assessment by HPLC, and verification of deuterium incorporation by mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Major peak at expected m/z
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.