Description

Crizotinib-D5 CAS NO 1395950-84-1 is a deuterated isotopologue of the targeted cancer therapy drug Crizotinib, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and clinical research for oncology treatments.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Crizotinib in biological matrices (plasma, serum, tissue).
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates accurate studies on absorption, distribution, metabolism, and excretion (ADME) of Crizotinib.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and pharmacokinetic analysis during clinical trials for non-small cell lung cancer (NSCLC) and other ALK-positive cancers.
• Pharmaceutical Quality Control: Used in method development and validation to ensure the specificity and accuracy of assays for drug substance and product analysis.
• Forensic and Doping Analysis: Applied in specialized testing protocols where precise identification and quantification of the parent drug are required.

Basic Information

Product Name	Crizotinib-D5
CAS No.	1395950-84-1
Molecular Formula	C21H17D5Cl2FN5O
Molecular Weight	450.36 g/mol (for C21H17D5Cl2FN5O)
Synonyms	(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine-d5; PF-02341066-d5; Xalkori-d5; Crizotinib (phenyl-d5); Crizotinib-d5 (deuterated at the phenyl ring); Deuterated Crizotinib; Crizotinib Internal Standard; Crizotinib Stable Isotope.
EINECS	Contact for details

Quality Control

Every batch of Crizotinib-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and the absence of critical impurities. Our quality commitment supports compliance with GLP and GMP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.