Description

3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, imparts significant electronic and steric properties that are highly sought after in the development of novel active compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating new drug candidates and crop protection agents with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new fluorinated compounds.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid
CAS No.	1395080-16-6
Molecular Formula	C₁₀H₆F₄O₂
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-(3-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid; 3-Fluoro-4-trifluoromethylcinnamic acid; (2E)-3-[3-Fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid; 3-Fluoro-4-(trifluoromethyl)benzeneacrylic acid; 2-Propenoic acid, 3-[3-fluoro-4-(trifluoromethyl)phenyl]-, (2E)-; 3-Fluoro-4-(trifluoromethyl)trans-cinnamic acid; 3-Fluoro-4-(trifluoromethyl)phenylacrylic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is light-sensitive and should be stored away from light. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.