Description

6-Bromo-2,3-Difluorothioanisole is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on a thioanisole core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a versatile precursor for the synthesis of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of halogenated aromatic systems.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic semiconductors and liquid crystals, where fluorine and bromine atoms fine-tune material properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the reactive bromine atom, enabling the formation of new carbon-carbon bonds.
• Ligand and Catalyst Development: Employed as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Chemical Biology Probes: Useful for creating fluorescent tags, affinity labels, and other molecular probes for studying biological systems and mechanisms.

Basic Information

Product Name	6-Bromo-2,3-Difluorothioanisole
CAS No.	1394291-28-1
Molecular Formula	C7H4BrF2S
Molecular Weight	239.08 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-(methylthio)benzene; 2,3-Difluoro-6-bromothioanisole; 4-Bromo-2,3-difluorophenyl methyl sulfide; Methyl 2,3-difluoro-6-bromophenyl sulfide; 6-Bromo-2,3-difluorophenyl methyl thioether
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2,3-Difluorothioanisole is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.