Description

Adamts 5 CAS NO 1394122-20-3 is a high-purity, small molecule compound designed for advanced research and development applications. This compound serves as a potent and selective inhibitor of the ADAMTS-5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5) enzyme, a key target in the study of extracellular matrix degradation. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who are investigating pathways related to osteoarthritis, cartilage biology, and other connective tissue disorders. The product is supplied under stringent quality controls to ensure reliable and reproducible results in demanding experimental settings.

Application

• Pharmaceutical Research: Used as a critical tool compound in drug discovery programs targeting osteoarthritis and other degenerative joint diseases.
• Biochemical Assay Development: Serves as a reference standard and positive control in enzymatic assays to study ADAMTS-5 activity and inhibition.
• Academic & Preclinical Studies: Facilitates fundamental research into the role of aggrecanases in cartilage breakdown and connective tissue physiology.
• Mechanism of Action (MoA) Studies: Enables detailed investigation of signaling pathways and validation of therapeutic targets in relevant disease models.
• High-Throughput Screening (HTS): Employed in screening libraries to identify novel scaffolds with ADAMTS-5 inhibitory activity.

Basic Information

Product Name	Adamts 5
CAS No.	1394122-20-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ADAMTS-5 Inhibitor; ADAMTS5 Inhibitor; Aggrecanase-2 Inhibitor; (2R,3S)-3-[(3S)-3-(4-Chlorophenyl)-2-oxo-5-oxazolidinyl]carbonylamino-2-hydroxy-4-phenylbutyl Phosphonic Acid; TISAM; CAS 1394122-20-3
EINECS	Contact for details

Quality Control

Every batch of Adamts 5 is produced and analyzed under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and assay results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.