Description

(2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Oxan-4-Yl)Propanoic Acid is a chiral, non-natural amino acid derivative featuring a Boc-protected amine and a tetrahydropyran (oxan-4-yl) side chain. This compound is a critical high-purity building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutic agents, including protease inhibitors and GPCR-targeted drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and central nervous system (CNS) diseases.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a constrained, heterocyclic side chain, influencing the secondary structure and bioavailability of peptide drugs.
• Protease Inhibitor Development: The tetrahydropyran moiety mimics transition states, making this compound valuable for creating inhibitors of serine and cysteine proteases.
• Chemical Biology & Proteomics: Serves as a building block for activity-based probes and labeled peptides used in target identification and mechanistic studies.
• Library Synthesis for Drug Discovery: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Academic Research: Used in university and institutional labs for fundamental studies in asymmetric synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	(2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Oxan-4-Yl)Propanoic Acid
CAS No.	1393524-16-7
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	Boc-D-4-Thp-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoic Acid; Boc-4-Thp-D-OH; D-Boc-4-Thp-OH; Boc-D-Tic(4-Thp)-OH; N-Boc-3-(Tetrahydropyran-4-yl)-D-alanine; N-(tert-Butoxycarbonyl)-3-(oxan-4-yl)-D-alanine; (R)-2-(Boc-amino)-3-(tetrahydropyran-4-yl)propionic Acid
EINECS	Contact for details

Quality Control

Our production of (2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Oxan-4-Yl)Propanoic Acid adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity >99% and standard identity/purity assays. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.