Description

n-Boc-3-(4-Bromo-2-Fluorophenyl)Propylamine is a high-purity, protected amine building block of significant importance in modern organic synthesis. This compound matters because it provides a versatile and reactive handle for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the bromo-fluorophenyl moiety can impart specific biological activity.
• Peptide Mimetics & PROTACs: Serves as a crucial linker or spacer component in the design of peptide mimetics and Proteolysis Targeting Chimeras (PROTACs).
• Material Science: Employed in the synthesis of specialty polymers and liquid crystals, where its aromatic and amine functionalities can modify material properties.
• Chemical Biology Probes: Utilized as a precursor for fluorescent tags or affinity probes to study biological pathways and protein interactions.
• Scale-up Process Chemistry: Suitable for use in kilogram-scale GMP and non-GMP production of advanced intermediates for clinical trial materials.

Basic Information

Product Name	n-Boc-3-(4-Bromo-2-Fluorophenyl)Propylamine
CAS No.	1393442-41-5
Molecular Formula	C14H19BrFNO2
Molecular Weight	332.21 g/mol
Synonyms	1-Boc-3-(4-Bromo-2-fluorophenyl)propylamine; tert-Butyl N-[3-(4-bromo-2-fluorophenyl)propyl]carbamate; 3-(4-Bromo-2-fluorophenyl)-1-propanamine, N-BOC-; N-Boc-3-(4-Bromo-2-fluoro-phenyl)-propylamine; N-(tert-Butoxycarbonyl)-3-(4-bromo-2-fluorophenyl)propan-1-amine; BOC-4-Bromo-2-fluorophenethylamine Propyl Amine; (3-(4-Bromo-2-fluorophenyl)propyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-3-(4-Bromo-2-Fluorophenyl)Propylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grade meets the high-purity requirements for research and development, with specifications customizable to meet specific project needs, including those for GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.