Description

2-Amino-5-Chloro-Isonicotinonitrile is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both an amino group and a nitrile moiety on a chlorinated pyridine ring, enabling diverse chemical transformations. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex molecular architectures, particularly in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, dyes, and pigments due to its conjugated system.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Amino-5-Chloro-Isonicotinonitrile
CAS No.	1393106-21-2
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	5-Chloro-2-aminopyridine-4-carbonitrile; 5-Chloro-2-aminoisonicotinonitrile; 2-Amino-5-chloro-4-cyanopyridine; 4-Cyano-5-chloro-2-aminopyridine; 5-Chloro-4-cyano-2-aminopyridine; 2-Amino-5-chloropyridine-4-carbonitrile; 1393106-21-2; 5-Chloro-2-amino-4-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-Isonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.