Description

Ketoconazole n-Oxide is a key pharmaceutical intermediate and metabolite of the antifungal agent ketoconazole. This compound is of significant interest for research and development in medicinal chemistry, particularly in the study of antifungal mechanisms and metabolic pathways. It serves as a critical building block for pharmaceutical manufacturers and research institutions focused on developing and analyzing advanced antifungal therapies.

Application

• Primary intermediate in the synthesis and research of advanced antifungal pharmaceutical agents.
• Reference standard for analytical method development and validation in quality control laboratories.
• Metabolite standard for pharmacokinetic and drug metabolism studies.
• Key starting material for the preparation of other specialized ketoconazole derivatives.
• Active Pharmaceutical Ingredient (API) intermediate for formulation research.
• Biochemical research tool for investigating fungal cytochrome P450 enzyme interactions.

Basic Information

Product Name	Ketoconazole n-Oxide
CAS No.	1392277-16-5
Molecular Formula	C₂₆H₂₈Cl₂N₄O₄
Molecular Weight	531.43 g/mol
Synonyms	Ketoconazole N-Oxide; 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one oxide; Ketoconazole Impurity; Ketoconazole Metabolite; cis-Ketoconazole N-Oxide
EINECS	Contact for details

Quality Control

Our Ketoconazole n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.