Description

Boc-(+/-)-trans-4-(3-Hydroxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a protected amino acid derivative featuring a pyrrolidine scaffold with a phenolic hydroxyl group. This compound serves as a versatile and critical chiral building block in modern organic synthesis, particularly for the construction of complex pharmacophores. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Peptidomimetic Synthesis: Used in the design and synthesis of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and receptor interactions.
• Academic and Industrial Research: A valuable tool for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis Building Block: Provides a functionalized, protected framework for custom synthesis services targeting specific client molecules.

Basic Information

Product Name	Boc-(+/-)-trans-4-(3-Hydroxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	1392214-14-0
Molecular Formula	C₁₇H₂₃NO₅
Molecular Weight	321.37 g/mol
Synonyms	trans-4-(3-Hydroxyphenyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-3-pyrrolidinecarboxylic Acid; tert-Butyl trans-4-(3-hydroxyphenyl)pyrrolidine-3-carboxylate-1-carboxylate; (3R*,4R*)-1-(tert-Butoxycarbonyl)-4-(3-hydroxyphenyl)pyrrolidine-3-carboxylic Acid; (±)-trans-1-Boc-4-(3-hydroxyphenyl)pyrrolidine-3-carboxylic Acid; Boc-trans-4-(3-Hydroxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid; Boc-4-(3-Hydroxyphenyl)pyrrolidine-3-carboxylic Acid; Boc-HPPC Acid
EINECS	Contact for details

Quality Control

Our Boc-(+/-)-trans-4-(3-Hydroxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.