Description

(±)-Ropivacaine-D7 (Propyl-D7) is a deuterated internal standard specifically designed for the quantitative analysis of the local anesthetic ropivacaine. This high-purity compound is essential for ensuring accuracy and reliability in sensitive analytical techniques, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, clinical research organizations, and forensic toxicology units requiring precise measurement of ropivacaine levels in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate quantification of ropivacaine in plasma, serum, and tissue samples using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic and Clinical Toxicology: Used for the definitive identification and measurement of ropivacaine in cases of suspected overdose or therapeutic drug monitoring.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of ropivacaine metabolites in biological systems.
• Method Development and Validation: Critical for establishing and validating robust, regulatory-compliant analytical methods in GLP/GMP environments.
• Drug Impurity and Degradation Studies: Can be utilized as a reference marker in stability-indicating assay methods for ropivacaine pharmaceutical formulations.

Basic Information

Item	Details
Product Name	(±)-Ropivacaine-D7 (Propyl-D7)
CAS No.	1392208-04-6
Molecular Formula	C₁₇H₂₀D₇N₂O
Molecular Weight	~287.45 g/mol
Synonyms	Ropivacaine-d7; (S)-(-)-Ropivacaine-d7 (Propyl-d7); 1-Propyl-2',6'-pipecoloxylidide-d7; 1-Propyl-2',6'-pipecoloxylidide-d7; Naropin-d7 (deuterated); N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide-d7; (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide-d7
EINECS	Contact for details

Quality Control

Every batch of (±)-Ropivacaine-D7 (Propyl-D7) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standard applications. Comprehensive testing includes assay, isotopic enrichment (D7), and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.