Description

(S)-Ethyl 2-(4-Fluorophenyl)-2-(4-Oxopiperidin-1-Yl)Acetate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry. This compound is essential for research institutions and manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other fine chemicals where the (S)-enantiomer is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and psychiatric disorders.
• API Development: Used in research and development for constructing the core scaffold of potential new chemical entities (NCEs) with specific stereochemical requirements.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chirality into more complex molecular architectures.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in academic and industrial R&D labs focusing on fluorinated piperidine derivatives.
• Pre-clinical Candidate Synthesis: Used in the scale-up synthesis of compounds for pre-clinical evaluation and toxicology studies.

Basic Information

Product Name	(S)-Ethyl 2-(4-Fluorophenyl)-2-(4-Oxopiperidin-1-Yl)Acetate
CAS No.	1391575-15-7
Molecular Formula	C15H18FNO3
Molecular Weight	279.31 g/mol
Synonyms	Ethyl (2S)-2-(4-fluorophenyl)-2-(4-oxopiperidin-1-yl)acetate; (S)-1-(Ethoxycarbonyl)(4-fluorophenyl)methyl]-4-piperidone; 1-[(1S)-1-(4-Fluorophenyl)-2-ethoxy-2-oxoethyl]piperidin-4-one; UNII-9F8Q3F3V8S; (S)-Ethyl 2-(4-fluorophenyl)-2-(4-oxo-1-piperidinyl)acetate; 4-Oxo-1-piperidineacetic acid, α-(4-fluorophenyl)-, ethyl ester, (αS)-; 9F8Q3F3V8S
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 2-(4-Fluorophenyl)-2-(4-Oxopiperidin-1-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.