Description

6β-Naltrexol 3-o-β-D-Glucuronide is a high-purity reference standard and active pharmaceutical ingredient (API) metabolite, crucial for advanced pharmaceutical research and development. This compound is essential for precise analytical work, including method development, validation, and bioanalytical studies in pharmacokinetics and metabolism. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on opioid antagonist research and therapeutic drug monitoring.

Application

• Pharmaceutical Reference Standard: Used as a certified primary standard for the quantitative and qualitative analysis of naltrexone and its metabolites in drug formulations and biological matrices.
• Metabolite Studies & Pharmacokinetics: Critical for investigating the metabolic pathways, bioavailability, and clearance rates of naltrexone in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating sensitive HPLC, LC-MS, and LC-MS/MS methods in compliance with GLP and GMP guidelines.
• Toxicology and Doping Control: Employed in forensic and sports anti-doping laboratories for the accurate detection and confirmation of opioid antagonist metabolites.
• Impurity Profiling: Used to identify and quantify related substances and degradation products in naltrexone API and finished drug products to ensure safety and efficacy.
• Clinical Research: Supports studies on opioid dependence treatment, aiding in the understanding of drug efficacy and patient response mechanisms.

Basic Information

Product Name	6β-Naltrexol 3-o-β-D-Glucuronide
CAS No.	1391506-73-2
Molecular Formula	C30H39NO11
Molecular Weight	589.63 g/mol
Synonyms	6β-Naltrexol Glucuronide; 6β-Naltrexol 3-Glucuronide; 6β-Naltrexol-3-O-β-D-glucuronide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-yl β-D-Glucopyranosiduronic Acid; Naltrexol Glucuronide; 6β-Naltrexol-3-O-glucuronide; 6β-Naltrexol D-Glucuronide
EINECS	Contact for details

Quality Control

Our 6β-Naltrexol 3-o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.