Description

1-[(1R,2S)-1-(Di-o-Tolylphosphinooxy)-1-Phenylpropan-2-Yl]-3-Phenylurea is a sophisticated chiral organophosphorus compound, specifically designed as a ligand precursor or catalyst component for asymmetric synthesis. Its value lies in enabling highly selective chemical transformations, which are critical for producing enantiomerically pure intermediates in pharmaceutical and fine chemical manufacturing. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serving as a precursor for chiral phosphine ligands in transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: Enabling the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Research: Facilitating the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process optimization in pilot-scale production.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, flavors, and fragrances where high enantiomeric purity is required.

Basic Information

Item	Details
Product Name	1-[(1R,2S)-1-(Di-o-Tolylphosphinooxy)-1-Phenylpropan-2-Yl]-3-Phenylurea
CAS No.	1391410-56-2
Molecular Formula	C31H31N2O2P
Molecular Weight	494.57 g/mol
Synonyms	(1R,2S)-1-(Di-o-tolylphosphinyloxy)-1-phenylpropan-2-yl-3-phenylurea; 1-[(1R,2S)-1-(Di-o-tolylphosphinyloxy)-1-phenylpropan-2-yl]-3-phenylurea; Chiral Urea-Phosphinite Ligand Precursor; Asymmetric Catalyst Ligand; (R,S)-Urea-Phosphinite Derivative; 1-Phenyl-3-[(1R,2S)-1-(phosphinoyloxy)-1-phenylpropan-2-yl]urea (o-tolyl substituted); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our 1-[(1R,2S)-1-(Di-o-Tolylphosphinooxy)-1-Phenylpropan-2-Yl]-3-Phenylurea is produced and tested under strict quality management systems to ensure high chiral purity and chemical integrity. Our products undergo rigorous quality testing, including chiral HPLC and NMR analysis, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.