Description

(tert-Butoxy)Carbonyl D-2-Iodotyrosine is a protected, non-natural amino acid derivative featuring an iodine substituent on the aromatic ring. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, particularly for pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic agents, including peptide-based drugs and targeted radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and hormone analogs.
• Radiopharmaceutical Precursor: The iodine atom provides a handle for radioiodination, making it valuable for developing diagnostic and therapeutic radiopharmaceuticals.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate iodotyrosine residues into peptide sequences for structure-activity relationship (SAR) studies.
• Bioconjugation & Probe Development: Serves as a building block for creating fluorescent probes, affinity labels, or other bioconjugates for biochemical and cellular imaging.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, protein-protein interactions, and signal transduction pathways where tyrosine halogenation is of interest.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) containing modified tyrosine.

Basic Information

Product Name	(tert-Butoxy)Carbonyl D-2-Iodotyrosine
CAS No.	1391385-17-3
Molecular Formula	C₁₄H₁₈INO₅
Molecular Weight	407.20 g/mol
Synonyms	Boc-D-2-Iodotyrosine; N-Boc-D-2-Iodotyrosine; D-2-Iodo-N-(tert-butoxycarbonyl)tyrosine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxy-3-iodophenyl)propanoic acid; Boc-D-Tyr(2-I)-OH; Boc-D-2-I-Tyr-OH; N-(tert-Butoxycarbonyl)-3-(3-iodo-4-hydroxyphenyl)-D-alanine
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl D-2-Iodotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, chiral integrity, and consistency. Certificates of Analysis (COA) are provided, detailing specifications such as assay (HPLC), chiral purity, and related substances. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.