Description

(S)-Rasagiline-13C3 Mesylate is a stable isotope-labeled analog of the active pharmaceutical ingredient rasagiline, where three carbon atoms are replaced with the carbon-13 isotope. This compound is a critical reference standard and internal standard used in quantitative analytical methods, particularly liquid chromatography-mass spectrometry (LC-MS). It is essential for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors who require precise and accurate measurement of rasagiline and its metabolites in complex biological matrices for pharmacokinetic studies, bioequivalence testing, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Serves as a primary chemical reference material for the identification and quantification of rasagiline in drug substances and finished products.
• Bioanalytical Internal Standard: Used as a stable isotope-labeled internal standard in LC-MS/MS assays to ensure accuracy and precision in measuring rasagiline concentrations in plasma, serum, and other biological fluids during clinical trials.
• Metabolite Studies: Facilitates the investigation of rasagiline's metabolic pathways and the identification of its metabolites in in vitro and in vivo studies.
• Impurity Profiling and Method Development: Aids in the development and validation of analytical methods for detecting and quantifying related substances and degradants in rasagiline mesylate active pharmaceutical ingredient (API).
• Doping Control Analysis: Potential use as a reference compound in sports anti-doping laboratories for the detection of rasagiline, which is prohibited in certain competitions.
• Forensic Toxicology: Employed in forensic science for the definitive identification and quantification of rasagiline in casework samples.

Basic Information

Product Name	(S)-Rasagiline-13C3 Mesylate
CAS No.	1391068-00-0
Molecular Formula	C12H1313C3H2N • CH4O3S
Molecular Weight	~284.3 g/mol (for 13C3 labeled form)
Synonyms	(1R)-N-(2-Propyn-1-yl)-2,3-dihydro-1H-inden-1-amine-13C3 methanesulfonate; Rasagiline-13C3 Mesylate; (R)-N-Propargyl-1-aminoindan-13C3 Mesylate; AGN 1135-13C3; TVP 1012-13C3 Mesylate; Azilect-13C3 (labeled reference standard); (S)-(-)-Rasagiline-13C3 Mesylate
EINECS	Contact for details

Quality Control

Every batch of (S)-Rasagiline-13C3 Mesylate is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to confirm identity, isotopic purity, chemical purity, and potency. Certificates of Analysis (COA) are supplied with each shipment, detailing results from tests including NMR for structural and isotopic confirmation, HPLC for chemical purity, and mass spectrometry for isotopic enrichment. Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical and pharmaceutical development environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Isotopic Purity (MS)	≥98% 13C3
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.