Description

2-Demethyl Colchicine 2-o-Sulfate is a chemically modified derivative of the natural alkaloid colchicine, designed for enhanced research utility and specific pharmacological studies. This compound is valued for its role as a key intermediate and reference standard in the development of novel therapeutic agents and biochemical probes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotech companies focused on anti-inflammatory and anti-cancer drug discovery.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and quality control in drug development pipelines.
• Biochemical Research: Serves as a critical intermediate or tool compound for studying tubulin polymerization inhibition and cellular mitosis.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research related to colchicine and its analogs.
• Preclinical Development: Acts as a starting material or synthetic precursor for creating novel derivatives with potential therapeutic applications.
• Academic Research: Utilized in university laboratories for investigating the structure-activity relationships (SAR) of colchicinoids.

Basic Information

Product Name	2-Demethyl Colchicine 2-o-Sulfate
CAS No.	1391052-56-4
Molecular Formula	C₂₁H₂₃NO₉S
Molecular Weight	465.47 g/mol
Synonyms	2-Demethylcolchicine 2-O-Sulfate; Colchicine, 2-demethyl-, 2-(hydrogen sulfate); 2-Desmethylcolchicine 2-O-Sulfate; 2-O-Sulfo-2-demethylcolchicine; 2-Demethylcolchicine Sulfate Ester; N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide 2-O-Sulfate; (S)-N-(1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide 2-O-Sulfate
EINECS	Contact for details

Quality Control

Our 2-Demethyl Colchicine 2-o-Sulfate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.