Description

(11Br)-8,9,10,11,12,13,14,15-Octahydro-N,n-Bis[(1R)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is a sophisticated chiral organophosphorus compound, valued for its role as a highly selective ligand or catalyst precursor in asymmetric synthesis. Its complex, sterically defined structure makes it a critical tool for researchers and process chemists developing enantioselective transformations. This compound is primarily targeted for use in pharmaceutical R&D, fine chemical synthesis, and advanced material science, where precise stereochemical control is paramount.

Application

• Asymmetric Catalysis: Serving as a chiral ligand for transition metals (e.g., Rh, Pd, Ir) in enantioselective hydrogenation, C-C bond formation, and other key synthetic transformations.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and metabolic conditions.
• Methodology Development: Used in academic and industrial research to discover and optimize new catalytic asymmetric reactions.
• Fine Chemical Production: Facilitating the manufacture of high-value chiral building blocks, flavors, and fragrances.
• Material Science Research: Potential application in the development of chiral polymers or frameworks with specific optical properties.

Basic Information

Product Name	(11Br)-8,9,10,11,12,13,14,15-Octahydro-N,n-Bis[(1R)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine
CAS No.	1389329-66-1
Molecular Formula	C37H37BrNO2P
Molecular Weight	638.58 g/mol
Synonyms	Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine, 8,9,10,11,12,13,14,15-octahydro-N,N-bis[(1R)-1-phenylethyl]-, 11-bromo-; (11-Br)-H8-BINAP(O) derivative; Chiral brominated BINOL-phosphoramidite ligand; P,N-Ligand based on octahydrobinaphthyl; (R)-BINAP(O)-type ligand, brominated.
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphoramidite compounds is produced and analyzed under strict quality protocols to ensure exceptional enantiomeric purity and chemical integrity. Standard quality control includes comprehensive analysis via HPLC, NMR (¹H, ³¹P), and chiral chromatography to confirm identity, purity, and enantiomeric excess (ee). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.