Description

8-Fluoro-5-Hydroxy-3,4-Dihydroquinolin-2(1H)-One is a fluorinated dihydroquinolinone derivative, a high-value pharmaceutical intermediate and building block in organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in medicinal chemistry for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique fluorinated quinoline scaffold.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore fluorination effects on potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and pesticides with enhanced efficacy.
• Fine Chemical Production: Employed in the custom synthesis of complex, fluorinated organic molecules for specialty applications.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for the development of novel fluorinated polymers and advanced organic materials.

Basic Information

Product Name	8-Fluoro-5-Hydroxy-3,4-Dihydroquinolin-2(1H)-One
CAS No.	1388025-60-2
Molecular Formula	C9H8FNO2
Molecular Weight	181.16 g/mol
Synonyms	8-Fluoro-5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one; 5-Hydroxy-8-fluoro-3,4-dihydro-2(1H)-quinolinone; 8-Fluoro-5-hydroxy-3,4-dihydro-1H-quinolin-2-one; 8-Fluoro-5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one; 1388025-60-2; 8-Fluoro-5-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline; Fluorinated dihydroquinolinone intermediate
EINECS	Contact for details

Quality Control

Our 8-Fluoro-5-Hydroxy-3,4-Dihydroquinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.