Description

Methyl (2S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Oxo-1L2-Pyrrolidin-3-Yl)Propanoate Hcl is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound matters as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily needed by pharmaceutical R&D and process chemistry teams for developing novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of bioactive peptides and protease inhibitors.
• Solid-Phase Peptide Synthesis (SPPS): Used as a Boc-protected amino acid ester monomer for the controlled elongation of peptide chains.
• Medicinal Chemistry Research: Serves as a crucial scaffold in the discovery and optimization of new drug candidates targeting neurological and metabolic disorders.
• Process Development: Employed in scaling up the production of active pharmaceutical ingredients (APIs) requiring specific pyrrolidinone-based motifs.
• Bioconjugation: Acts as a specialized linker or spacer molecule for creating peptide-drug conjugates or labeled biomolecules.
• Academic & Institutional Research: Fundamental building block in organic chemistry and chemical biology studies exploring novel amino acid derivatives.

Basic Information

Product Name	Methyl (2S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Oxo-1L2-Pyrrolidin-3-Yl)Propanoate Hydrochloride
CAS No.	1385184-01-9
Molecular Formula	C14H23N2O5 • HCl
Molecular Weight	338.80 g/mol (Free base: 299.34 g/mol)
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(2-oxo-1-pyrrolidin-3-yl)propanoic acid methyl ester hydrochloride; Methyl (2S)-2-(Boc-amino)-3-(2-oxopyrrolidin-3-yl)propanoate HCl; Boc-3-(2-Oxopyrrolidin-3-yl)-L-alanine methyl ester hydrochloride; Boc-L-2-Oxopyrrolidine-3-yl-Ala-OMe • HCl; 1385184-01-9; Boc-3-(2-Oxopyrrolidin-3-yl)-Ala-OMe hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Oxo-1L2-Pyrrolidin-3-Yl)Propanoate Hcl is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.