Description

1,2-Azetidinedicarboxylic Acid, 2-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)- is a high-purity, chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex, biologically active molecules with precise stereochemistry. Pharmaceutical R&D and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of novel therapeutic agents, particularly for constructing constrained peptide mimetics and β-lactam analogs.
• Peptidomimetic Synthesis: Used to introduce the azetidine-2-carboxylic acid scaffold, a conformationally restricted surrogate for proline, into peptide chains to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds for medicinal chemistry and material science.
• Protecting Group Chemistry: The 9-fluorenylmethyl (Fmoc) ester moiety is a standard, orthogonal protecting group for carboxylic acids in multi-step synthesis, especially in solid-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Academic & Industrial R&D: Essential for research laboratories in universities and contract research organizations (CROs) focused on synthetic methodology and new chemical entity discovery.

Basic Information

Product Name	1,2-Azetidinedicarboxylic Acid, 2-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)-
CAS No.	1384745-40-7
Molecular Formula	C21H19NO4
Molecular Weight	349.38 g/mol
Synonyms	(2S)-1-(9H-Fluoren-9-ylmethyl) 2-methylazetidine-1,2-dicarboxylate; Fmoc-Aze(2-Me)-OH; 1-Fmoc-2-methylazetidine-2-carboxylic acid; (S)-1-((9H-Fluoren-9-yl)methyl) 2-methylazetidine-1,2-dicarboxylate; 2-Methylazetidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester, (2S)-; Fmoc-2-methyl-Aze-OH; Nα-Fmoc-2-methylazetidine-2-carboxylic acid; (S)-2-Methyl-1-((((9H-fluoren-9-yl)methoxy)carbonyl)azetidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1,2-Azetidinedicarboxylic Acid, 2-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)- adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.