Description

(3As,7As)-2-(((2R,4R)-4-(((3As,7As)-1,3-Diphenyloctahydro-2H-Isophosphindol-2-Yl)Oxy)Pentan-2-Yl)Oxy)-1,3-Diphenyloctahydro-1H-Benzo[D][1,3,2]Diazaphosphole is a sophisticated, high-purity chiral organophosphorus compound, serving as a critical building block in advanced chemical synthesis. Its value lies in its unique stereochemistry and functional groups, which make it an essential ligand or intermediate for creating enantiomerically pure pharmaceuticals and specialty chemicals. This product is primarily needed by research institutions and industrial R&D departments focused on asymmetric catalysis, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: As a chiral ligand or catalyst precursor in transition metal-catalyzed reactions for the synthesis of enantiomerically enriched compounds.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chiral Auxiliary: Employed to induce chirality in synthetic pathways, enabling the production of single-isomer compounds.
• Specialty Chemical Synthesis: For the development of advanced materials, agrochemicals, and fine chemicals requiring specific stereochemical configurations.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical spaces in synthetic organic chemistry.

Basic Information

Product Name	(3As,7As)-2-(((2R,4R)-4-(((3As,7As)-1,3-Diphenyloctahydro-2H-Isophosphindol-2-Yl)Oxy)Pentan-2-Yl)Oxy)-1,3-Diphenyloctahydro-1H-Benzo[D][1,3,2]Diazaphosphole
CAS No.	1384535-76-5
Molecular Formula	C41H48N2O2P2
Molecular Weight	662.78 g/mol
Synonyms	(3aR,7aR)-2-{[(2R,4R)-4-{[(3aR,7aR)-1,3-Diphenyloctahydro-2H-isoindol-2-yl]oxy}pentan-2-yl]oxy}-1,3-diphenyloctahydro-1H-benzo[d][1,3,2]diazaphosphole; 1,3-Diphenyloctahydro-1H-benzo[d][1,3,2]diazaphosphole Derivative; Chiral Diazaphosphole-Isophosphindole Ligand; CAS 1384535-76-5; Benzodiazaphosphole Intermediate; Chiral Organophosphorus Ligand; Asymmetric Synthesis Reagent
EINECS	Contact for details

Quality Control

Our production of this high-value chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and purity. Each lot undergoes comprehensive analytical characterization, including chiral HPLC, NMR, and mass spectrometry, to confirm identity and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical specifications. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.