Description

2-(1-Aminocyclobutyl)Acetamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutyl amine structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of new therapeutic agents, particularly in areas requiring constrained, small-ring systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: Supplied for process development and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	2-(1-Aminocyclobutyl)Acetamide Hydrochloride
CAS No.	1384428-91-4
Molecular Formula	C6H13ClN2O
Molecular Weight	164.63 g/mol
Synonyms	2-(1-Aminocyclobutyl)acetamide hydrochloride; 2-(1-Aminocyclobutyl)ethanamide hydrochloride; Acetamide, 2-(1-aminocyclobutyl)-, hydrochloride; 1-(2-Amino-2-oxoethyl)cyclobutanamine hydrochloride; Cyclobutanamine, 1-(2-amino-2-oxoethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(1-Aminocyclobutyl)Acetamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.