Description

5-Amino-2-Bromoisonicotinonitrile is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both amino and bromo substituents on a cyano-substituted pyridine ring, makes it a versatile precursor for constructing complex nitrogen-containing scaffolds. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor modulators, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science Research: Serves as a building block for creating functionalized polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Heterocyclic Library Construction: Fundamental for parallel and combinatorial synthesis to create diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	5-Amino-2-Bromoisonicotinonitrile
CAS No.	1384080-97-0
Molecular Formula	C6H4BrN3
Molecular Weight	198.02 g/mol
Synonyms	2-Bromo-5-aminopyridine-4-carbonitrile; 4-Cyano-2-bromo-5-aminopyridine; 5-Amino-2-bromo-4-cyanopyridine; 2-Bromo-5-aminoisonicotinonitrile; 5-Amino-2-bromopyridine-4-carbonitrile; 1384080-97-0; 5-Amino-2-bromo-4-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Bromoisonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.