Description

2,5-Difluoro-4-(Methylsulfanyl)Phenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical synthesis. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing complex biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing difluorinated and thioether motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and OLED (Organic Light-Emitting Diode) components.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Scale-up and Process Chemistry: Suitable for process optimization and pilot-scale synthesis due to the stability offered by the pinacol ester protecting group.

Basic Information

Product Name	2,5-Difluoro-4-(Methylsulfanyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1383968-47-5
Molecular Formula	C13H17BF2O2S
Molecular Weight	286.15 g/mol
Synonyms	4-(Methylthio)-2,5-difluorophenylboronic acid pinacol ester; 2,5-Difluoro-4-(methylthio)benzeneboronic acid pinacol ester; 2,5-Difluoro-4-(methylsulfanyl)phenylboronic acid pinacol ester; 4-Methylsulfanyl-2,5-difluorophenylboronic acid pinacol ester; (4-(Methylthio)-2,5-difluorophenyl)boronic acid pinacol ester; Pinacol [2,5-difluoro-4-(methylthio)phenyl]boronate; B-[2,5-Difluoro-4-(methylthio)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-(Methylsulfanyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere for prolonged manipulations to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.