Description

10-Deacetyl-7,10-Dimethoxy-Baccatin Iii-D6 is a deuterated derivative of a key baccatin III intermediate, a crucial scaffold in the synthesis of taxane-based pharmaceuticals. This compound is specifically designed for use as an internal standard in analytical methods, enabling precise quantification and metabolic studies in pharmaceutical research and development. It is an essential material for scientists and manufacturers in the pharmaceutical and biotechnology sectors working on complex natural product synthesis and advanced analytical method development.

Application

• Analytical Reference Standard: Primary use as a high-purity internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of taxane derivatives.
• Pharmaceutical R&D: Critical tool in the research, development, and quality control of paclitaxel, docetaxel, and other taxane-based chemotherapeutic agents.
• Metabolic Studies: Enables tracking and quantification of drug metabolites in pharmacokinetic and pharmacodynamic studies due to its stable deuterium labels.
• Process Chemistry: Used in the development and optimization of synthetic routes for complex taxane molecules in process scale-up.
• Impurity Profiling: Aids in the identification and characterization of related substances and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	10-Deacetyl-7,10-Dimethoxy-Baccatin Iii-D6
CAS No.	1383325-07-2
Molecular Formula	C31H32D6O11
Molecular Weight	~592.64 g/mol
Synonyms	10-Deacetyl-7,10-dimethoxybaccatin III-d6; Baccatin III, 10-deacetyl-7,10-dimethoxy-, hexadeuterio-; 7,10-Dimethoxy-10-deacetylbaccatin III-d6; Deuterated Baccatin III Derivative; Taxane Intermediate-d6; Internal Standard for Taxol Analysis-d6; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-4,6,9,11,12a-pentahydroxy-4a,8,13,13-tetramethyl-7,10-dimethoxy-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-2-yl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate-d6
EINECS	Contact for details

Quality Control

Our 10-Deacetyl-7,10-Dimethoxy-Baccatin Iii-D6 is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR (¹H & ¹³C) for structural confirmation and deuterium incorporation, and HPLC for purity assessment, to ensure it meets the high standards required for analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), isotopic enrichment, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.