Description

Human Activin A CAS NO 1381885-28-4 is a high-purity recombinant protein belonging to the transforming growth factor-beta (TGF-β) superfamily. This signaling molecule is essential for regulating critical cellular processes including proliferation, differentiation, and apoptosis. It is a fundamental research and development reagent for scientists and manufacturers in the biotechnology, pharmaceutical, and stem cell research sectors.

Application

• Stem Cell Research & Differentiation: Key for directing the differentiation of pluripotent stem cells into definitive endoderm and mesoderm lineages.
• Cell Culture & Media Supplement: Used as a critical growth factor in specialized cell culture systems to maintain specific cell phenotypes.
• Developmental Biology Studies: Investigates its role in embryonic development, organogenesis, and tissue patterning.
• Drug Discovery & Screening: Employed in assays targeting the activin signaling pathway for therapeutic development.
• Biomanufacturing of Specialized Cells: Supports the production of specific cell types for regenerative medicine and cell therapy applications.
• Endocrinology Research: Studies its function in the regulation of follicle-stimulating hormone (FSH) secretion and reproductive biology.

Basic Information

Product Name	Human Activin A
CAS No.	1381885-28-4
Molecular Formula	Contact for details
Molecular Weight	~25 kDa (dimer)
Synonyms	Activin A; Activin Beta A Homodimer; Recombinant Human Activin A; rhActivin A; INHBA Homodimer; Follicle-Stimulating Hormone Releasing Protein; FRP; EDF; Erythroid Differentiation Factor
EINECS	Contact for details

Quality Control

Our Human Activin A is produced under stringent conditions and undergoes comprehensive analytical testing to ensure high biological activity, purity, and consistency. Quality is verified through multiple methods including SDS-PAGE, HPLC, and bioassays. Each batch is supported by a detailed Certificate of Analysis (COA) providing full characterization data, including purity, endotoxin levels, and biological activity. We adhere to relevant quality management standards for research-grade biologics.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 98%
Biological Activity	Determined by cell-based assay (EC50)
Endotoxin Level	< 1.0 EU/μg
Identification (Mass Spec)	Consistent with theoretical molecular weight
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.