Description

n-Fmoc-4-(2-Chlorophenyl)-L-Phenylalanine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of a sterically hindered, chlorinated phenylalanine analog into peptide chains. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where specific aromatic interactions are desired.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for automated and manual peptide assembly.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to modulate bioavailability, receptor binding affinity, and metabolic stability.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Material Science: Building block for constructing peptide-conjugated polymers or surface coatings with specific properties.
• Agrochemical Research: Potential use in developing peptide-inspired active ingredients.

Basic Information

Product Name	n-Fmoc-4-(2-Chlorophenyl)-L-Phenylalanine
CAS No.	1381787-76-3
Molecular Formula	C30H24ClNO4
Molecular Weight	497.97 g/mol
Synonyms	Fmoc-4-(2-Chlorophenyl)-L-Phe-OH; Fmoc-2'-Chloro-[1,1'-biphenyl]-4-yl-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(2-chlorophenyl)-L-phenylalanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(2-chlorophenyl)phenyl]propanoic acid; Fmoc-L-Phe(2-Cl-Ph)-OH; N-α-Fmoc-4-(2-Chlorophenyl)-L-phenylalanine; Protected 2'-Chlorobiphenyl-4-ylalanine derivative
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-(2-Chlorophenyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.