Description

n-Fmoc-4-(3-Chlorophenyl)-L-Phenylalanine is a protected, non-natural amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides a crucial building block for creating complex peptides with enhanced stability and specific biological activity, enabling research into novel therapeutics and diagnostics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing peptide-based drugs, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential construction of custom peptide sequences.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of novel peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate a chlorophenyl side chain into peptide backbones, modifying their interaction with biological targets for drug discovery.
• Bioconjugation & Probe Development: Facilitates the synthesis of labeled peptides for use in diagnostic assays, imaging, and targeted drug delivery systems.
• Chemical Biology Studies: Enables the exploration of protein-protein interactions and enzyme function through the introduction of specific structural motifs.
• Material Science: Potential use in creating specialized peptide-based polymers and biomaterials with tailored properties.

Basic Information

Product Name	n-Fmoc-4-(3-Chlorophenyl)-L-Phenylalanine
CAS No.	1380437-47-7
Molecular Formula	C30H24ClNO4
Molecular Weight	497.97 g/mol
Synonyms	Fmoc-4-(3-Chlorophenyl)-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(3-chlorophenyl)-L-phenylalanine; Fmoc-3-Cl-Phe(4)-OH; Fmoc-(4-(3-Chlorophenyl))-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[4-(3-chlorophenyl)phenyl]propanoic acid; N-α-Fmoc-4-(3-Chlorophenyl)-L-phenylalanine; Protected 3-Chlorophenylphenylalanine derivative; Fmoc-L-Phe(4-3-Cl-Ph)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-(3-Chlorophenyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are available for every lot upon request, supporting compliance in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.