Description

n-(4E)-Tco-L-Lysine is a specialized, high-purity chemical building block featuring a trans-cyclooctene (TCO) moiety for bioorthogonal click chemistry applications. Its core value lies in enabling rapid, selective, and catalyst-free conjugation with tetrazine-functionalized molecules, which is critical for advanced bioconjugation and labeling workflows. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic reagent production who require efficient and reliable site-specific modification of biomolecules.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, peptides, and oligonucleotides via inverse electron-demand Diels-Alder (IEDDA) reactions.
• Proteomics Research: Used in chemical proteomics for labeling and enrichment of target biomolecules in complex biological samples.
• Pre-targeting Strategies: A key component in radioimmunotherapy and imaging, where the TCO group is attached to a targeting vector for subsequent capture by a radiolabeled tetrazine.
• Diagnostic Kit Development: Enables the creation of sensitive and specific diagnostic assays through controlled conjugation of detection labels.
• Materials Science: Functionalization of surfaces, nanoparticles, and polymers with bio-recognition elements for biosensor and biomaterial applications.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of novel, stable linker-payload attachment strategies in ADC platforms.

Basic Information

Product Name	n-(4E)-Tco-L-Lysine
CAS No.	1380349-88-1
Molecular Formula	C14H24N2O2
Molecular Weight	252.35 g/mol
Synonyms	(2S)-6-[(E)-trans-Cyclooct-4-en-1-yloxy]-2-aminohexanoic acid; (S)-2-Amino-6-((trans-cyclooct-4-en-1-yl)oxy)hexanoic acid; TCO-L-Lysine; trans-Cyclooct-4-en-1-yloxy-L-lysine; L-Lysine, N6-[(1E,4E)-cyclooct-1,4-dien-1-yl]-, (S)-; TCO amine; Bioorthogonal TCO linker; Click chemistry reagent TCO
EINECS	Contact for details

Quality Control

Our n-(4E)-Tco-L-Lysine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and the integrity of the reactive TCO group. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.