Description

(4-{[2-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylphenyl-tetrahydropyran scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic disorders. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery, enabling the exploration of new pharmacophores.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents, where the fluorine-containing moiety can impart desirable properties like pest selectivity and environmental persistence.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of specialty polymers or advanced organic materials with specific electronic or surface properties.

Basic Information

Product Name	(4-{[2-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine
CAS No.	1380300-67-3
Molecular Formula	C14H18F3NO
Molecular Weight	273.30 g/mol
Synonyms	4-({[2-(Trifluoromethyl)phenyl]methyl}oxy)tetrahydro-2H-pyran-4-methanamine; 1-[4-(Aminomethyl)tetrahydro-2H-pyran-4-yl]methyl-2-(trifluoromethyl)benzene; (4-{[2-(Trifluoromethyl)benzyl]oxy}tetrahydro-2H-pyran-4-yl)methanamine; 2-(Trifluoromethyl)benzyl 4-(aminomethyl)tetrahydro-2H-pyran-4-yl ether; 4-(Aminomethyl)-4-{[2-(trifluoromethyl)phenyl]methoxy}tetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our production of (4-{[2-(Trifluoromethyl)Phenyl]Methyl}Oxan-4-Yl)Methanamine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development grade specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.