Description

2-[3,5-Bis(Trifluoromethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane CAS NO 1380288-30-1 is a high-value, organoboron building block characterized by its electron-deficient aromatic system and protected boronic ester functionality. This compound matters for its critical role in enabling complex cross-coupling reactions, particularly Suzuki-Miyaura couplings, where it offers enhanced reactivity and stability compared to its boronic acid counterpart. It is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors who require precise and reliable synthetic intermediates for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those containing trifluoromethylphenyl groups for improved metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable and reactive boron reagent for forming carbon-carbon bonds between aromatic rings, a fundamental transformation in medicinal and process chemistry.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the trifluoromethyl groups contribute to biological activity and environmental persistence.
• Materials Science Research: Employed in the creation of novel organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its unique electronic and structural properties.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and tags for studying biological processes, leveraging the boron atom for further functionalization or detection.
• Catalyst Ligand Precursor: Acts as a precursor for sophisticated ligand systems in transition metal catalysis.

Basic Information

Product Name	2-[3,5-Bis(Trifluoromethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane
CAS No.	1380288-30-1
Molecular Formula	C13H13BF6O2
Molecular Weight	326.05 g/mol
Synonyms	5,5-Dimethyl-2-[3,5-bis(trifluoromethyl)phenyl]-1,3,2-dioxaborinane; [3,5-Bis(trifluoromethyl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane; 2-(3,5-Bis(trifluoromethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3,5-Bis(trifluoromethyl)benzeneboronic acid, 5,5-dimethyl-1,3,2-dioxaborinane ester; (3,5-Bis(trifluoromethyl)phenyl)boronic acid pinacol ester (common name for analogous pinacol boronate); B-[3,5-Bis(trifluoromethyl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Every batch of 2-[3,5-Bis(Trifluoromethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and process-scale applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency, identity, and purity. Certificates of Analysis (COA) detailing specific results for assay, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container must be kept tightly sealed and allowed to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.