Description

[1-(2S,5S)-2,5-Dimethylphospholanyl]-[2-(2S,5S)-2,5-Dimethylphospholanyl-1-Oxide]Benzene is a specialized chiral phosphine-oxazoline hybrid ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to optimize stereoselective synthesis.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high stereocontrol.
• Hydrosilylation Processes: Used as a chiral inducer in the asymmetric hydrosilylation of ketones and imines.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of enantiomerically pure active pharmaceutical ingredients (APIs) for CNS, cardiovascular, and oncology drugs.
• Agrochemical Synthesis: Applied in the creation of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling novel asymmetric processes in industry.

Basic Information

Product Name	[1-(2S,5S)-2,5-Dimethylphospholanyl]-[2-(2S,5S)-2,5-Dimethylphospholanyl-1-Oxide]Benzene
CAS No.	1380079-15-1
Molecular Formula	C18H28OP2
Molecular Weight	322.36 g/mol
Synonyms	(S,S)-[1-(2,5-Dimethylphospholanyl)]-[2-(2,5-dimethylphospholanyl-1-oxide)]benzene; (S,S)-DMPO-Benzene Ligand; Chiral DMPO-Based P,O-Ligand; (2S,5S)-2,5-Dimethylphospholane benzene P-oxide derivative; Asymmetric phosphine-oxazoline ligand; Josiphos-type analog ligand; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality control protocols to ensure exceptional purity and enantiomeric excess, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing purity (by HPLC/NMR), chiral purity, and identity confirmation. Our quality system supports development under cGMP guidelines for pharmaceutical applications, and we comply with relevant global chemical regulations including REACH.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this product should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.